Prolactin Receptor anticorps (C-Term) (Fluoro647)

N° du produit ABIN8025781

Cet anticorps anti-Prolactin Receptor Polyclonal Lapin conjugué à Fluoro647 (ABIN8025781) détecte spécifiquement Prolactin Receptor dans FACS. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Prolactin Receptor anticorps (C-Term) (Fluoro647) (ABIN8025781)

Antigène: Prolactin Receptor (PRLR)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prolactin Receptor est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-Prolactin Receptor anticorps (Fluoro647)

Épitope: C-Term

Fonction: Anti-Prolactin Receptor/PRLR Antibody Fluoro647 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related rat sequence,and different from the related human sequence by three amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of mouse PRLR, identical to the related rat sequence, and different from the related human sequence by three amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Prolactin Receptor

Antigène: Prolactin Receptor (PRLR)

Autre désignation: PRLR

Sujet:

Background: PRLR (Prolactin Receptor), is a cytokine receptor. By somatic cell hybrid analysis and by in situ hybridization, Arden et al. (1989, 1990) demonstrated that the prolactin receptor gene resides in the same chromosomal region as the growth hormone receptor gene, which has been mapped to 5p13-p12. Cunningham et al. (1990) demonstrated that zinc greatly increases the affinity of GH for the extracellular binding domain of PRLR, although it is not required for binding of GH to the growth hormone receptor or for binding of prolactin to the prolactin receptor. By mutational analysis, they showed that a cluster of 3 residues (histidine-18, histidine-21, and glutamic acid-174) in GH and histidine-188 in PRLR (conserved in all PRL receptors but not GH receptors) are likely zinc-ion ligands.

Gene Full Name: prolactin receptor

Sequence Similarities: Belongs to the type I cytokine receptor family. Type 1 subfamily.

ID gène: 19116

UniProt: Q08501

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus