PIAS4 anticorps (C-Term) (APC)

N° du produit ABIN8027340

L’anticorps anti-PIAS4 Polyclonal Lapin est utilisé pour la détection de PIAS4 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour PIAS4 anticorps (C-Term) (APC) (ABIN8027340)

Antigène: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIAS4 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-PIAS4 anticorps (APC)

Épitope: C-Term

Fonction: Anti-E3 SUMO-protein ligase PIAS4 Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: identical to the related mouse,rat sequences.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human PIAS4, identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PIAS4

Antigène: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Autre désignation: PIAS4

Sujet:

Background: E3 SUMO-protein ligase PIAS4, also known as protein inhibitor of activated STAT protein 4 (PIAS4) or protein inhibitor of activated STAT protein gamma (PIASg or PIASy) is an enzyme that in humans is encoded by the PIAS4 gene. This gene is mapped to 19p13.3. This gene plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. It functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This gene involved in gene silencing.

Gene Full Name: protein inhibitor of activated STAT 4

Sequence Similarities: Belongs to the PIAS family.

ID gène: 51588

UniProt: Q8N2W9

Pathways: Signalistation JAK/STAT, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus