PNP anticorps (Middle Region) (APC)

N° du produit ABIN8028963

L’anticorps anti-PNP Monoclonal Souris est utilisé pour la détection de PNP dans des échantillons de Humain et Rat. Il a été validé pour FACS.

Aperçu rapide pour PNP anticorps (Middle Region) (APC) (ABIN8028963)

Antigène: PNP (Purine Nucleoside Phosphorylase (PNP))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PNP est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Clone: 2H10

Détail du produit anti-PNP anticorps (APC)

Épitope: Middle Region

Fonction: Anti-PNP Antibody (monoclonal, 2H10) APC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse sequence by six amino acids,and from the related rat sequence by five amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human PNP, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PNP

Antigène: PNP (Purine Nucleoside Phosphorylase (PNP))

Autre désignation: PNP

Sujet:

Background: The PNP gene encodes purine nucleoside phosphorylase, an enzyme that catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. It is presented results from gene dosage studies consistent with assignment of the PNP locus to band 14q13. PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. Genetic deficiencies of PNP result in severely compromised Tlymphocyte function and neurologic dysfunction.

Gene Full Name: purine nucleoside phosphorylase

ID gène: 4860

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus