PKM anticorps (N-Term) (Cy3)

N° du produit ABIN8029420

Cet anticorps anti-PKM Monoclonal Souris conjugué à Cy3 (Clone 11I4C3) (ABIN8029420) détecte spécifiquement PKM dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PKM anticorps (N-Term) (Cy3) (ABIN8029420)

Antigène: PKM (Pyruvate Kinase M1/2 (PKM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PKM est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Clone: 11I4C3

Détail du produit anti-PKM anticorps (Cy3)

Épitope: N-Term

Fonction: Anti-PKM2 Antibody (monoclonal, 11I4C3) Cy3 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse sequence by five amino acids,and from the related rat sequence by four amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human PKM2, different from the related mouse sequence by five amino acids, and from the related rat sequence by four amino acids.

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PKM

Antigène: PKM (Pyruvate Kinase M1/2 (PKM))

Autre désignation: PKM

Sujet:

Background: PKM (Pyruvate Kinase, Muscle), also known as PK3 or PKM2, is an enzyme that in humans is encoded by the PKM gene. The activity of pyruvate kinase subtype M2 is increased by fructose 1, 6-bisphosphate (Fru-1, 6-P2). By in situ hybridization, Popescu and Cheng (1990) mapped the THBP1 gene to 15q24-q25. Ashizawa et al. (1991) manipulated the intracellular Fru-1, 6-P2 concentration in several mammalian cell lines, including human, by varying the glucose concentration in the media. Using a novel proteomic screen for phosphotyrosine-binding proteins, Christofk et al. (2008) observed that PKM2 binds ly and selectively to tyrosine-phosphorylated peptides.

Gene Full Name: pyruvate kinase M1/2

ID gène: 5315

UniProt: P14618

Pathways: L'effet Warburg