Dystroglycan anticorps (pTyr892)

N° du produit ABIN753463

Cet anticorps Lapin Polyclonal détecte spécifiquement Dystroglycan dans WB, ELISA, IF (cc), IF (p), IHC (p) et IHC (fro). Il présente une réactivité envers Rat.

Aperçu rapide pour Dystroglycan anticorps (pTyr892) (ABIN753463)

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dystroglycan est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Dystroglycan anticorps

Épitope: pTyr892

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human DAG1 around the phosphorylation site of Tyr892

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Dystroglycan

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Autre désignation: DAG1

Sujet:

Synonyms: DAG1 Tyr892, DAG1 Y892, p-DAG1Tyr892, Alpha Dystroglycan phospho Y892, AGRNR, Alpha-DG, Beta-DG, Beta-dystroglycan, beta Dystroglycan, DAG, Dag1, DAG1_HUMAN, Dystroglycan 1 dystrophin-associated glycoprotein 1, Dystroglycan, Dystrophin-associated glycoprotein 1, 156DAG, A3a, Dystrophin-associated glycoprotein 1.

Background: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]

ID gène: 1605

Pathways: Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus