RPA2 anticorps (AA 34-254) (Fluoro647)

N° du produit ABIN8031595

Cet anticorps anti-RPA2 Monoclonal Souris conjugué à Fluoro647 (Clone 3B2E9) (ABIN8031595) détecte spécifiquement RPA2 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour RPA2 anticorps (AA 34-254) (Fluoro647) (ABIN8031595)

Antigène: RPA2 (Replication Protein A2, 32kDa (RPA2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RPA2 est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Clone: 3B2E9

Détail du produit anti-RPA2 anticorps (Fluoro647)

Épitope: AA 34-254

Fonction: Anti-RPA32/RPA2 Antibody (monoclonal, 3B2E9) Fluoro647 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human RPA32/RPA2 recombinant protein (Position: Q34-H254).

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur RPA2

Antigène: RPA2 (Replication Protein A2, 32kDa (RPA2))

Autre désignation: RPA2

Sujet:

Background: This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways.

Gene Full Name: replication protein A2

ID gène: 6118

UniProt: P15927

Pathways: Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA