RNF111 anticorps (AA 134-994) (Fluoro647)

N° du produit ABIN8033172

L’anticorps anti-RNF111 Polyclonal Lapin est utilisé pour la détection de RNF111 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour RNF111 anticorps (AA 134-994) (Fluoro647) (ABIN8033172)

Antigène: RNF111 (Ring Finger Protein 111 (RNF111))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF111 est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-RNF111 anticorps (Fluoro647)

Épitope: AA 134-994

Fonction: Anti-RNF111 Antibody Fluoro647 Conjugated

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human RNF111 recombinant protein (Position: F134-S994).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur RNF111

Antigène: RNF111 (Ring Finger Protein 111 (RNF111))

Autre désignation: RNF111

Sujet:

Background: E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene. The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: ring finger protein 111

ID gène: 54778

UniProt: Q6ZNA4