RNF43 anticorps (AA 24-197) (Fluoro594)

N° du produit ABIN8033343

L’anticorps anti-RNF43 Polyclonal Lapin est utilisé pour la détection de RNF43 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour RNF43 anticorps (AA 24-197) (Fluoro594) (ABIN8033343)

Antigène: RNF43 (Ring Finger Protein 43 (RNF43))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF43 est conjugé à/à la Fluoro594

Application: Flow Cytometry (FACS)

Détail du produit anti-RNF43 anticorps (Fluoro594)

Épitope: AA 24-197

Fonction: Anti-RNF43 Antibody Fluoro594 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human RNF43 recombinant protein (Position: G24-Y197).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur RNF43

Antigène: RNF43 (Ring Finger Protein 43 (RNF43))

Autre désignation: RNF43

Sujet:

Background: RNF43 is a HAP95 (AKAP8L) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer. The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: ring finger protein 43

ID gène: 54894

UniProt: Q68DV7

Pathways: Signalisation WNT