RMI2 anticorps (AA 23-147) (Cy3)

N° du produit ABIN8033450

Cet anticorps Lapin Polyclonal détecte spécifiquement RMI2 dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour RMI2 anticorps (AA 23-147) (Cy3) (ABIN8033450)

Antigène: RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RMI2 est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Détail du produit anti-RMI2 anticorps (Cy3)

Épitope: AA 23-147

Fonction: Anti-C16orf75/RMI2 Antibody Cy3 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human RMI2 shares 87.2% amino acid (aa) sequence identity with mouse RMI2.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human C16orf75/RMI2 recombinant protein (Position: L23-P147). Human RMI2 shares 87.2% amino acid (aa) sequence identity with mouse RMI2.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur RMI2

Antigène: RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))

Autre désignation: RMI2

Sujet:

Background: RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. This gene is mapped to 16p13.13. RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components, including topoisomerase-3-alpha (TOP3A), RPA (see RPA1), and BLAP250. RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted ly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90 % . Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact. Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange.

Gene Full Name: RecQ mediated genome instability 2

ID gène: 116028

UniProt: Q96E14

Pathways: Réparation de l'ADN