LRP5 anticorps (AA 501-600) (HRP)

N° du produit ABIN754087

Cet anticorps Lapin Polyclonal détecte spécifiquement LRP5 dans IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour LRP5 anticorps (AA 501-600) (HRP) (ABIN754087)

Antigène: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP5 est conjugé à/à la HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-LRP5 anticorps (HRP)

Épitope: AA 501-600

Fonction: LRP5 Polyclonal Antibody, HRP Conjugated

Specificité: This antibody will recognize LRP6 due to high sequence similarity.

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human LRP5

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur LRP5

Antigène: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Autre désignation: LRP5

Sujet:

Synonyms: HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, LRP-5, OPTA1, VBCH2, Low-density lipoprotein receptor-related protein 5, LRP5

Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

ID gène: 4041

UniProt: O75197

Pathways: Signalisation WNT, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation