SLC38A9 anticorps (AA 33-450) (FITC)

N° du produit ABIN8040209

Cet anticorps Lapin Polyclonal détecte spécifiquement SLC38A9 dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SLC38A9 anticorps (AA 33-450) (FITC) (ABIN8040209)

Antigène: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC38A9 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-SLC38A9 anticorps (FITC)

Épitope: AA 33-450

Fonction: Anti-SLC38A9 Antibody FITC Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SLC38A9 recombinant protein (Position: D33-Q450).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur SLC38A9

Antigène: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Autre désignation: SLC38A9

Sujet:

Background: Solute carrier family 38 member 9 is a protein that in humans is encoded by the SLC38A9 gene. Sodium-coupled neutral amino acid transporter 9 (SLC38A9) is a lysosomal amino acid transporter, involved in the regulation of mechanistic target of rapamycin complex 1 (mTORC1) activity in response to amino acid levels within the lysosomal lumen. A sodium-couple amino acid transporter at the lysosome, SLC38A9, senses arginine from within the lysosome to convey arginine sufficiency to mTORC1. SLC38A9 forms a complex with other lysosomal resident proteins including the v-ATPase and a pentameric complex called Ragulator. v-ATPase function is necessary for mTORC1 activation, but the molecular mechanism of this regulation is currently unclear2. Ragulator binds strongly to the Rag GTPases and was shown to function as a guanine exchange factor (GEF) for RagA/B. Potentially SLC38A9 and the v-ATPase are able to regulate mTORC1 activity by modulating Ragulator's GEF activity. RagA/B is not the only Rag GTPase that is regulated, but a Folliculin-FNIP2 complex is a GAP for RagC/D. In short, SLC38A9 is a functional component of the lysosomal amino acid sensing machinery involved in the control of mTORC1 activity, that underlies the regulation of the metabolic status and cellular responses to growth factors, energy, glucose and amino acid levels.

Gene Full Name: solute carrier family 38 member 9

ID gène: 153129

UniProt: Q8NBW4