SMPD3 anticorps (AA 184-553) (Fluoro647)

N° du produit ABIN8041683

L’anticorps anti-SMPD3 Polyclonal Lapin est utilisé pour la détection de SMPD3 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour SMPD3 anticorps (AA 184-553) (Fluoro647) (ABIN8041683)

Antigène: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMPD3 est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Détail du produit anti-SMPD3 anticorps (Fluoro647)

Épitope: AA 184-553

Fonction: Anti-SMPD3 Antibody Fluoro647 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human SMPD3 shares 88.9% amino acid (aa) sequence identity with both mouse,rat SMPD3.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SMPD3 recombinant protein (Position: F184-D553). Human SMPD3 shares 88.9% amino acid (aa) sequence identity with both mouse and rat SMPD3.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur SMPD3

Antigène: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Autre désignation: SMPD3

Sujet:

Background: Sphingomyelin phosphodiesterase 3 is an enzyme that in humans is encoded by the SMPD3 gene. SMPD3 (Sphingomyelin phosphodiesterase 3, also Neutral sphingomyelinase 2/nSMase2) is a 69-74 kDa member of the neutral sphingomyelinase family of enzymes. It is a monomeric Golgi/plasma membrane enzyme that converts sphingomyelin (a plasma membrane lipid) into ceramide and phosphorylcholine. This generates second messenger components that participate in signal transduction. Human SMPD3 is a two transmembrane, 655 amino acids molecule. It contains an N-terminal luminal segment (aa 1-10), a cytoplasmic region (aa 32-64), and one catalytic domain (aa 340-646). Phosphorylation increases its MW to 78 kDa in SDS-PAGE. There is one potential isoform that possesses an Asn substitution for aa 569-587. Over aa 2-655, human SMPD3 shares 91 % aa sequence identity with mouse SMPD3.

Gene Full Name: sphingomyelin phosphodiesterase 3

ID gène: 55512

UniProt: Q9NY59

Pathways: Hormone Transport