SMPD3 anticorps (AA 184-553)

N° du produit ABIN8041684

Cet anticorps anti-SMPD3 Polyclonal Lapin (ABIN8041684) détecte spécifiquement SMPD3 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SMPD3 anticorps (AA 184-553) (ABIN8041684)

Antigène: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMPD3 est non-conjugé

Application: Western Blotting (WB), ELISA

Classe de qualité: Carrier-free

Détail du produit anti-SMPD3 anticorps

Épitope: AA 184-553

Fonction: Anti-SMPD3 Antibody

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human SMPD3 shares 88.9% amino acid (aa) sequence identity with both mouse,rat SMPD3.

Attributs du produit: Anti-SMPD3 Antibody. Tested in WB, ELISA applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SMPD3 recombinant protein (Position: F184-D553). Human SMPD3 shares 88.9% amino acid (aa) sequence identity with both mouse and rat SMPD3.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur SMPD3

Antigène: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Autre désignation: SMPD3

Sujet:

Background: Sphingomyelin phosphodiesterase 3 is an enzyme that in humans is encoded by the SMPD3 gene. SMPD3 (Sphingomyelin phosphodiesterase 3, also Neutral sphingomyelinase 2/nSMase2) is a 69-74 kDa member of the neutral sphingomyelinase family of enzymes. It is a monomeric Golgi/plasma membrane enzyme that converts sphingomyelin (a plasma membrane lipid) into ceramide and phosphorylcholine. This generates second messenger components that participate in signal transduction. Human SMPD3 is a two transmembrane, 655 amino acids molecule. It contains an N-terminal luminal segment (aa 1-10), a cytoplasmic region (aa 32-64), and one catalytic domain (aa 340-646). Phosphorylation increases its MW to 78 kDa in SDS-PAGE. There is one potential isoform that possesses an Asn substitution for aa 569-587. Over aa 2-655, human SMPD3 shares 91 % aa sequence identity with mouse SMPD3.

Gene Full Name: sphingomyelin phosphodiesterase 3

Poids moléculaire: 75 kDa

ID gène: 55512

UniProt: Q9NY59

Pathways: Hormone Transport