SENP6 anticorps (AA 135-1086) (APC)

N° du produit ABIN8043519

L’anticorps anti-SENP6 Polyclonal Lapin est utilisé pour la détection de SENP6 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour SENP6 anticorps (AA 135-1086) (APC) (ABIN8043519)

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP6 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-SENP6 anticorps (APC)

Épitope: AA 135-1086

Fonction: Anti-SENP6 Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SENP6 recombinant protein (Position: R135-K1086).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur SENP6

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Autre désignation: SENP6

Sujet:

Background: Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene. It is mapped to 6q14.1. Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.

Gene Full Name: SUMO specific peptidase 6

ID gène: 26054

UniProt: Q9GZR1