TDG anticorps (AA 15-370)

N° du produit ABIN8046543

L’anticorps anti-TDG Polyclonal Lapin est utilisé pour la détection de TDG dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IF, FACS et ICC.

Aperçu rapide pour TDG anticorps (AA 15-370) (ABIN8046543)

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TDG est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Classe de qualité: Carrier-free

Détail du produit anti-TDG anticorps

Épitope: AA 15-370

Fonction: Anti-TDG Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-TDG Antibody. Tested in ELISA, Flow Cytometry, ICC/IF, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human TDG recombinant protein (Position: Q15-R370).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur TDG

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Autre désignation: TDG

Sujet:

Background: G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.

Gene Full Name: thymine DNA glycosylase

Poids moléculaire: 55-60 kDa

ID gène: 6996

UniProt: Q13569

Pathways: Réparation de l'ADN, Chromatin Binding