XIAP anticorps (AA 15-244) (Fluoro488)

N° du produit ABIN8054593

Cet anticorps anti-XIAP Monoclonal Souris conjugué à Fluoro488 (Clone 3G2G1) (ABIN8054593) détecte spécifiquement XIAP dans FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour XIAP anticorps (AA 15-244) (Fluoro488) (ABIN8054593)

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp XIAP est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Clone: 3G2G1

Détail du produit anti-XIAP anticorps (Fluoro488)

Épitope: AA 15-244

Fonction: Anti-XIAP Antibody (monoclonal, 3G2G1) Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human XIAP shares 89.4%,90.7% amino acid (aa) sequence identity with mouse,rat XIAP,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human XIAP recombinant protein (Position: A15-V244). Human XIAP shares 89.4% and 90.7% amino acid (aa) sequence identity with mouse and rat XIAP, respectively.

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur XIAP

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Autre désignation: XIAP

Sujet:

Background: XIAP, also known as IAP3 or BIRC4, is a protein that stops apoptotic cell death. It is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants.

Gene Full Name: X-linked inhibitor of apoptosis

ID gène: 331

UniProt: P98170

Pathways: Apoptose, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis