GLI1 anticorps (AA 800-1057) (PE)

N° du produit ABIN8055281

Cet anticorps Lapin Polyclonal détecte spécifiquement GLI1 dans FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GLI1 anticorps (AA 800-1057) (PE) (ABIN8055281)

Antigène: GLI1 (Zinc Finger Protein GLI1 (GLI1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLI1 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-GLI1 anticorps (PE)

Épitope: AA 800-1057

Fonction: Anti-GLI1 Antibody PE Conjugated

Homologie: Human GLI1 shares 79.8% amino acid (aa) sequence identity with mouse GLI1.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human GLI1 recombinant protein (Position: Y800-Q1057). Human GLI1 shares 79.8% amino acid (aa) sequence identity with mouse GLI1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur GLI1

Antigène: GLI1 (Zinc Finger Protein GLI1 (GLI1))

Autre désignation: GLI1

Sujet:

Background: GLI1, also known as GLI, is a protein originally isolated in human glioblastoma. The protein is encoded by GLI1 gene. It is mapped to 12q13.3. This gene is a member of a select group of cellular genes that are genetically altered in primary human tumors. GLI1 encodes a member of the GLI-Kruppel family of zinc finger proteins in the final steps of Hedgehog signaling in normal development and disease. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Beside, various upstream patterning signals may be integrated by the Gli proteins to a coherent programme of neurogenesis.

Gene Full Name: GLI family zinc finger 1

ID gène: 2735

UniProt: P08151

Pathways: Signalisation Hedgehog, Dopaminergic Neurogenesis