FCN3 anticorps

N° du produit ABIN8065466

Cet anticorps Souris Monoclonal détecte spécifiquement FCN3 dans ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour FCN3 anticorps (ABIN8065466)

Antigène: FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FCN3 est non-conjugé

Application: ELISA

Classe de qualité: Carrier-free

Clone: FCN334

Détail du produit anti-FCN3 anticorps

Fonction: Anti-H-Ficolin Antibody

Specificité: ABIN8065465 reacts specifically with H-ficolin. No cross-reaction has been observed with L- or M-ficolin.

Homologie: Human

Purification: Protein A or Protein G purified

Immunogène: Recombinant human H-ficolin

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 12 months

Détails sur FCN3

Antigène: FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3))

Autre désignation: H-Ficolin

Sujet: FCN3, FCNH, HAKA1, ficolin-3, H-ficolin, collagen/fibrinogen domain-containing lectin 3 p35, collagen/fibrinogen domain-containing protein 3, ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen),Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11907111, PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically binds N-Acetylglucosamine (GlcNAc,) GalNAc (N-acetylgalactosamine) and D-fucose on the surface of pathogens, as well as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (PubMed:17215869). {ECO:0000269|PubMed:11907111, ECO:0000269|PubMed:15804047, ECO:0000269|PubMed:17215869, ECO:0000269|PubMed:26133042}.,FCN3,H-Ficolin (Hakata antigen, Ficolin-3) is an innate immunity pattern recognition molecule found in human serum. H-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) formed by carbohydrates (GlcNAc, GalNAc and fucose) activating complement through the lectin pathway by means of the associated MASPs ((MBL)-associated serine proteases). H-Ficolin consists of 35 kDa protein chains associated in triplet subunits which are again associated in high molecular weight oligomers by means of disulfide bonds at the N-terminal region.

Poids moléculaire: 35 kDa

ID gène: 8547

UniProt: O75636

Pathways: Système du Complément