GLP-1 anticorps (N-Term)

N° du produit ABIN8065491

L’anticorps anti-GLP-1 Monoclonal Souris est utilisé pour la détection de GLP-1 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour GLP-1 anticorps (N-Term) (ABIN8065491)

Antigène: GLP-1 (Glucagon-like peptide 1 (GLP-1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GLP-1 est non-conjugé

Application: Western Blotting (WB), ELISA

Classe de qualité: Carrier-free

Clone: 49

Détail du produit anti-GLP-1 anticorps

Épitope: N-Term

Fonction: Anti-GLP-1 (9-37) and GLP-1 (9-36) amide (N-term) Antibody

Specificité: ABS 044-49 binds human GLP-1(9-36)amide. Based on inhibition ELISA, ABS 044-49 cross-reacts 3 % with GLP-1(7-36)amide. The free N-terminus of GLP-1(9-36)amide and GLP-1(9-37).

Homologie: Human

Purification: Protein A or Protein G purified

Immunogène: Synthetic GLP-1(9-18)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur GLP-1

Antigène: GLP-1 (Glucagon-like peptide 1 (GLP-1))

Autre désignation: GLP-1

Sujet: GCG, GLP-1, GLP1, GLP2, GRPP, pro-glucagon, glicentin-related polypeptide, glucagon-like peptide 1, glucagon-like peptide 2, incretin, preproglucagon,Glucagon-like peptide 1. Potent stimulator of glucose-dependent insulin release (PubMed:22037645, PubMed:40446798). Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels (PubMed:10605628, PubMed:14719035, PubMed:12554744). May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin (PubMed:10605628, PubMed:14719035, PubMed:12554744). Has growth-promoting activities on intestinal epithelium (PubMed:10605628, PubMed:14719035, PubMed:12554744). May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion (PubMed:10605628, PubMed:14719035, PubMed:12554744). Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation (PubMed:10605628, PubMed:14719035, PubMed:12554744). Inhibits beta cell apoptosis (PubMed:10605628, PubMed:14719035, PubMed:12554744).,GCG,Glucagon-like peptide-1(9-36)amide and GLP-1(9-37) are the forms of GLP-1 that result from the rapid degradation of the active forms of the peptide (GLP-1(7-36)amide and GLP-1(7-37)) by the enzyme dipeptidyl peptidase-IV (DPP-IV, also known as CD26 or adenosine deaminase binding protein). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.

Poids moléculaire: 20 kDa (proglucagon)

ID gène: 2641

UniProt: P01275