CXCR5 anticorps

N° du produit ABIN8093081

L’anticorps anti-CXCR5 Monoclonal Souris est utilisé pour la détection de CXCR5 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour CXCR5 anticorps (ABIN8093081)

Antigène: CXCR5 (Chemokine (C-X-C Motif) Receptor 5 (CXCR5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CXCR5 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: CXCR5-13095

Détail du produit anti-CXCR5 anticorps

Fonction: CXCR5 Antibody / CD185

Immunogène: A recombinant fragment of human CXCR5 protein (exact sequence is proprietary) was used as the immunogen for the C-X-C Motif Chemokine Receptor 5/CD185 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the C-X-C Motif Chemokine Receptor 5/CD185 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: C-X-C Motif Chemokine Receptor 5/CD185 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur CXCR5

Antigène: CXCR5 (Chemokine (C-X-C Motif) Receptor 5 (CXCR5))

Autre désignation: CXCR5

Sujet: C-X-C Motif Chemokine Receptor 5 antibody, also known as CD185 antibody, recognizes C-X-C motif chemokine receptor 5, a seven-transmembrane G protein-coupled receptor encoded by the CXCR5 gene and commonly referred to as Burkitt lymphoma receptor 1. C-X-C Motif Chemokine Receptor 5 is primarily localized to the plasma membrane of B lymphocytes and subsets of T cells, particularly follicular helper T cells, where it regulates chemokine-driven cell migration. As a member of the CXC chemokine receptor family, CXCR5 binds the ligand CXCL13 and plays a central role in lymphoid follicle organization and germinal center formation.

C-X-C Motif Chemokine Receptor 5 antibody detects a multi-pass transmembrane receptor composed of seven alpha-helical membrane-spanning domains, extracellular regions responsible for ligand recognition, and intracellular domains that couple to heterotrimeric G proteins. Upon binding CXCL13, CXCR5 activates downstream signaling pathways that promote cytoskeletal rearrangement and directed chemotaxis. Through these mechanisms, CD185 directs B cells and T follicular helper cells into B cell follicles within secondary lymphoid tissues, supporting antibody affinity maturation and adaptive immune responses.

Functionally, CXCR5 is essential for proper germinal center architecture and humoral immunity. Expression of C-X-C Motif Chemokine Receptor 5 defines follicular B cells and T follicular helper cells and is widely used as a marker in immunophenotyping and lymphoid tissue studies. Dysregulated CXCR5 signaling has been implicated in autoimmune diseases, chronic inflammatory conditions, and lymphoid malignancies. In certain B cell lymphomas, altered CD185 expression may influence tumor cell positioning and interactions within the lymphoid microenvironment.

The CXCR5 gene is located on chromosome 11 and is transcriptionally regulated during lymphocyte activation and differentiation. Because C-X-C Motif Chemokine Receptor 5 expression is largely restricted to specific immune cell subsets, detection of this receptor provides insight into lymphocyte trafficking, germinal center dynamics, and immune cell compartmentalization in normal and disease contexts.

The C-X-C Motif Chemokine Receptor 5 antibody (clone CXCR5/13095) is suitable for detecting CXCR5 protein expression in research applications. This CD185 antibody supports investigation of B cell biology, T follicular helper cell function, lymphoid tissue organization, and immune-mediated disease mechanisms.

UniProt: P32302