MUC13 anticorps (AA 226-312)

N° du produit ABIN8093333

L’anticorps anti-MUC13 Polyclonal Lapin est utilisé pour la détection de MUC13 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IF et IHC (p).

Aperçu rapide pour MUC13 anticorps (AA 226-312) (ABIN8093333)

Antigène: MUC13 (Mucin 13, Cell Surface Associated (MUC13))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUC13 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MUC13 anticorps

Épitope: AA 226-312

Fonction: MUC13 Antibody / Mucin 13

Purification: Antigen affinity purified

Immunogène: Amino acids E226-S312 from the human protein were used as the immunogen for the MUC13 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MUC13 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: Store the MUC13 antibody at -20oC.

Détails sur MUC13

Antigène: MUC13 (Mucin 13, Cell Surface Associated (MUC13))

Autre désignation: MUC13

Sujet: MUC13 Antibody targets Mucin 13, a transmembrane mucin encoded by the MUC13 gene that functions as a component of the epithelial cell surface glycocalyx. Mucin 13 belongs to the mucin family of heavily glycosylated proteins that contribute to epithelial barrier function, cell signaling, and protection of mucosal surfaces. As a membrane-associated mucin, MUC13 plays a role in mediating interactions between epithelial cells and their extracellular environment.

Functionally, Mucin 13 contributes to epithelial defense by forming a protective mucous layer and participating in cell surface signaling processes. The extracellular mucin domain is extensively glycosylated, providing resistance to proteolytic degradation and mechanical stress, while the transmembrane and cytoplasmic regions enable intracellular signaling interactions. A MUC13 Antibody enables investigation of mucin expression patterns, epithelial surface organization, and mucin-associated signaling pathways in research studies.

MUC13 expression is primarily observed in epithelial tissues, particularly within the gastrointestinal tract and other mucosal surfaces. At the cellular level, Mucin 13 localizes predominantly to the apical plasma membrane of epithelial cells, where it contributes to barrier integrity and luminal interface functions. Altered localization or expression of MUC13 may reflect changes in epithelial differentiation, inflammatory responses, or disease-associated remodeling of mucosal tissues.

At the molecular level, Mucin 13 is characterized by a large extracellular domain containing tandem repeat regions rich in serine and threonine residues that serve as sites for O-linked glycosylation. These structural features are typical of mucins and are critical for forming hydrated, protective mucous layers. The cytoplasmic tail of MUC13 contains motifs that can interact with intracellular signaling proteins, linking mucin expression to regulation of epithelial cell behavior.

From a biological and disease relevance perspective, MUC13 has been extensively studied in cancer research, particularly in epithelial-derived malignancies. Aberrant overexpression of MUC13 has been associated with altered cell signaling, increased proliferative capacity, and changes in cell adhesion properties. These alterations can contribute to tumor-associated epithelial remodeling and disrupted barrier function, highlighting the importance of MUC13 as a marker of epithelial transformation and disease progression.

MUC13 Antibody reagents are valuable tools for studying mucin biology, epithelial barrier regulation, and disease-associated changes in cell surface glycoproteins. These antibodies support research into gastrointestinal biology, epithelial signaling pathways, and cancer-associated alterations in mucosal protein expression. NSJ Bioreagents provides MUC13 Antibody products intended for research use.

UniProt: Q9H3R2