Recombinant PAX2A anticorps (AA 223-354)

N° du produit ABIN8093384

L’anticorps anti-PAX2A Monoclonal Souris est utilisé pour la détection de PAX2A dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Recombinant PAX2A anticorps (AA 223-354) (ABIN8093384)

Antigène: PAX2A (Paired Box Gene 2a (PAX2A))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX2A est non-conjugé

Application: Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Clone: RPAX2-8506

Détail du produit anti-PAX2A anticorps

Épitope: AA 223-354

Fonction: PAX2 Antibody / Paired box protein Pax-2 (azide and preservative free)

Immunogène: A recombinant fragment (around amino acids 223-354) of human PAX2 protein (exact sequence is proprietary) was used as the immunogen for the Paired box protein 2/PAX2 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Paired box protein 2/PAX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Paired box protein 2/PAX2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Détails sur PAX2A

Antigène: PAX2A (Paired Box Gene 2a (PAX2A))

Autre désignation: PAX2

Sujet: Paired box protein 2 antibody, also known as PAX2 antibody, recognizes a nuclear transcription factor commonly referred to as Paired box protein Pax-2 and Paired box gene 2. Paired box protein 2 is encoded by the PAX2 gene located on chromosome 10q24 and belongs to the paired box family of developmental regulators. The protein localizes predominantly to the nucleus, where it functions as a DNA-binding transcription factor controlling gene expression during embryogenesis and tissue differentiation. PAX2 is highly expressed during kidney, urogenital tract, eye, ear, and central nervous system development, with limited expression in most normal adult tissues.

Paired box protein 2 plays a central role in nephric duct formation, renal morphogenesis, and optic nerve development by regulating genes involved in cell proliferation, survival, and lineage specification. Through its transcriptional activity, it coordinates developmental signaling pathways including Wnt and growth factor-mediated cascades. Paired box protein 2 antibody is widely used in developmental biology and tumor research to study renal differentiation and to identify neoplasms of renal or Mullerian origin. In adult tissues, PAX2 expression can be reactivated during tissue repair or oncogenic transformation.

Structurally, Paired box protein 2 contains a conserved paired DNA-binding domain and a partial homeodomain that enable sequence-specific transcriptional regulation. It interacts with co-regulators and chromatin-modifying complexes to activate or repress target genes. Alternative splicing generates multiple isoforms that may contribute to tissue-specific regulatory functions and developmental stage-dependent expression patterns.

Dysregulated PAX2 expression is associated with tumorigenesis. Elevated nuclear PAX2 levels are frequently detected in renal cell carcinoma, Wilms tumor, ovarian carcinoma, and certain endometrial carcinomas. Its characteristic nuclear staining pattern in tumor epithelial cells makes it a valuable diagnostic biomarker in pathology. Germline mutations in PAX2 are linked to congenital anomalies of the kidney and urinary tract, highlighting its importance in organ development.

Paired box protein 2 antibody supports research in embryonic development, renal pathology, and cancer biology. Recombinant monoclonal clone rPAX2/8506 recognizes PAX2 and is suitable for detecting Paired box protein 2 expression in relevant research applications.

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation