PGAM2 anticorps (N-Term)

N° du produit ABIN8093409

Cet anticorps anti-PGAM2 Polyclonal Lapin (ABIN8093409) détecte spécifiquement PGAM2 dans WB, IHC, IF et FACS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PGAM2 anticorps (N-Term) (ABIN8093409)

Antigène: PGAM2 (phosphoglycerate Mutase 2 (Muscle) (PGAM2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PGAM2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-PGAM2 anticorps

Épitope: N-Term

Fonction: PGAM2 Antibody / Phosphoglycerate mutase 2

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Phosphoglycerate mutase 2 was used as the immunogen for the PGAM2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PGAM2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PGAM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PGAM2

Antigène: PGAM2 (phosphoglycerate Mutase 2 (Muscle) (PGAM2))

Autre désignation: PGAM2

Sujet: PGAM2 antibody targets Phosphoglycerate mutase 2, encoded by the PGAM2 gene. Phosphoglycerate mutase 2 is a cytoplasmic enzyme that catalyzes the reversible interconversion of 3-phosphoglycerate and 2-phosphoglycerate during glycolysis. As a muscle-enriched isoform of phosphoglycerate mutase, PGAM2 plays a critical role in regulating glycolytic flux in tissues with high energetic demand.

Functionally, Phosphoglycerate mutase 2 contributes to efficient ATP production by facilitating a key step in the central glycolytic pathway. Its activity supports rapid energy generation required for muscle contraction and other energy-intensive cellular processes. A PGAM2 antibody supports studies focused on carbohydrate metabolism, glycolytic regulation, and metabolic adaptation in differentiated tissues.

PGAM2 is predominantly localized to the cytoplasm, consistent with its role in glycolysis. Although highly enriched in skeletal and cardiac muscle, PGAM2 expression can also be detected in other cell types under conditions that demand increased glycolytic activity. This distribution reflects a balance between tissue specialization and broader metabolic responsiveness.

From a disease-related perspective, altered PGAM2 expression or activity has been investigated in muscle disorders, metabolic disease, and cancer. Changes in glycolytic enzyme expression can influence cellular energy balance, proliferation, and stress tolerance. As such, Phosphoglycerate mutase 2 is frequently studied in contexts linking metabolism to disease-associated phenotypes.

At the molecular level, Phosphoglycerate mutase 2 functions as a dimeric enzyme and contains conserved catalytic residues required for phosphotransfer activity. Its apparent behavior in biochemical assays may vary depending on metabolic state and post-translational regulation without altering its primary structure. PGAM2 antibody reagents enable investigation of glycolytic enzyme regulation and cellular metabolism, with NSJ Bioreagents providing reagents intended for research use.

UniProt: P15259