PDCD6 anticorps (N-Term)

N° du produit ABIN8093426

L’anticorps anti-PDCD6 Polyclonal Lapin est utilisé pour la détection de PDCD6 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et FACS.

Aperçu rapide pour PDCD6 anticorps (N-Term) (ABIN8093426)

Antigène: PDCD6 (Programmed Cell Death 6 (PDCD6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDCD6 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-PDCD6 anticorps

Épitope: N-Term

Fonction: PDCD6 Antibody / Programmed cell death protein 6

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Programmed cell death protein 6 protein was used as the immunogen for the PDCD6 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PDCD6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PDCD6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PDCD6

Antigène: PDCD6 (Programmed Cell Death 6 (PDCD6))

Autre désignation: PDCD6

Sujet: PDCD6 antibody targets Programmed cell death protein 6, encoded by the PDCD6 gene. Programmed cell death protein 6, also known as ALG-2, is a calcium-binding protein that belongs to the penta-EF-hand family. It is predominantly localized in the cytoplasm and nucleus and functions as a calcium-dependent signaling adaptor rather than a classical enzyme. PDCD6 was originally identified through its involvement in apoptosis-related pathways but is now recognized as a broader regulator of intracellular signaling and membrane trafficking.

Functionally, Programmed cell death protein 6 responds to changes in intracellular calcium levels and undergoes conformational changes that enable interactions with multiple partner proteins. Through these interactions, PDCD6 participates in processes such as apoptosis regulation, vesicle trafficking, and endosomal sorting. It has been shown to associate with components of the ESCRT machinery and other signaling proteins, linking calcium signaling to membrane dynamics. A PDCD6 antibody supports studies focused on calcium-dependent signaling and apoptotic regulation.

PDCD6 is widely expressed across tissues and cell types, reflecting its involvement in fundamental cellular processes. Its activity is particularly relevant in cells undergoing dynamic calcium signaling or stress responses. Subcellular localization of PDCD6 can vary depending on calcium availability and interacting partners, allowing it to act as a flexible signaling mediator within the cell.

From a disease-relevance perspective, Programmed cell death protein 6 has been investigated in cancer, immune regulation, and neurodegenerative conditions. Altered PDCD6 expression or signaling has been associated with changes in apoptosis sensitivity, tumor progression, and inflammatory responses. These findings highlight PDCD6 as a protein of interest in studies examining how calcium-dependent pathways influence disease-associated cellular behavior.

At the molecular level, Programmed cell death protein 6 contains multiple EF-hand motifs that coordinate calcium binding and protein-protein interactions. Calcium-dependent conformational changes and post-translational regulation can influence its apparent behavior in biochemical assays without altering the primary amino acid sequence. PDCD6 antibody reagents support research applications focused on apoptosis, calcium signaling, and intracellular trafficking, with NSJ Bioreagents providing reagents intended for research use.

UniProt: O75340

Pathways: Positive Regulation of Endopeptidase Activity