KSR2 anticorps (N-Term)

N° du produit ABIN8103917

L’anticorps anti-KSR2 Polyclonal Lapin est utilisé pour la détection de KSR2 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour KSR2 anticorps (N-Term) (ABIN8103917)

Antigène: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KSR2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KSR2 anticorps

Épitope: N-Term

Fonction: KSR2 Antibody - N-terminal region

Séquence: LQQCELVQNM IDLSISNLEG LRTKCATSND LTQKEIRTLE SKLVKYFSRQ

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human KSR2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP62199-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur KSR2

Antigène: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Autre désignation: KSR2

Sujet:

Background Information: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Gene Name: kinase suppressor of ras 2

Protein Name: Kinase suppressor of Ras 2

Poids moléculaire: 108 kDa

ID gène: 283455

UniProt: Q6VAB6