p107 anticorps (C-Term)

N° du produit ABIN8110390

Cet anticorps Lapin Polyclonal détecte spécifiquement p107 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour p107 anticorps (C-Term) (ABIN8110390)

Antigène: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p107 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-p107 anticorps

Épitope: C-Term

Fonction: RBL1 Antibody - C-terminal region

Séquence: NMIRQGEQRT KKRVIAIDSD AESPAKRVCQ ENDDVLLKRL QDVVSERANH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human RBL1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31025-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur p107

Antigène: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Autre désignation: RBL1

Sujet:

Background Information: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: RB transcriptional corepressor like 1

Alternative Symbols: PRB1, p107, CP107

Protein Name: Retinoblastoma-like protein 1

Poids moléculaire: 121 kDa

ID gène: 5933

NCBI Accession: NP_002886

UniProt: P28749

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases