FBXW7 anticorps (Biotin)

N° du produit ABIN760918

Cet anticorps Lapin Polyclonal détecte spécifiquement FBXW7 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache) et Porc.

Aperçu rapide pour FBXW7 anticorps (Biotin) (ABIN760918)

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW7 est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FBXW7 anticorps (Biotin)

Réactivité croisée: Boeuf (Vache), Chien, Humain, Souris, Porc, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FBW7

Isotype: IgG

Information d'application

Indications d'application: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur FBXW7

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Autre désignation: FBW7

Sujet:

Synonyms: AGO, Archipelago homolog, Archipelago, Drosophila, homolog of antibody CDC4, DKFZp686F23254, F box and WD 40 domain protein 7 archipelago homolog, Drosophila, F box and WD 40 domain protein 7, F box and WD repeat domain containing 7, F box protein FBW7, F box protein FBX30, F box protein SEL10, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW6, FBW7, FBX30, FBXO30, FBXW6, FBXW7, FBXW7_HUMAN, FLJ16457, hAgo, hCdc4, Homolog of C elegans sel 10, Homolog of C.elegans sel10, SEL-10, SEL10.

Background: Fbw7 is a member of the F box protein family which are characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F box), which function in phosphorylation-dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. Fbw7 belongs to the Fbws class, in addition to an F box, this protein contains 7 tandem WD40 repeats. It binds directly to cyclin E and probably targets cyclin E for ubiquitin mediated degradation. Mutations of this gene are detected in ovarian and breast cancer cell lines. Alternative splicing of this gene generates 2 transcript variants diverging at the 5' termini.

Poids moléculaire: 69/110kDa

ID gène: 55294

Pathways: Signalisation Notch, EGFR Signaling Pathway