ACER1 anticorps (AA 100-180)

N° du produit ABIN8119660

Cet anticorps anti-ACER1 Polyclonal Lapin (ABIN8119660) détecte spécifiquement ACER1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ACER1 anticorps (AA 100-180) (ABIN8119660)

Antigène: ACER1 (Alkaline Ceramidase 1 (ACER1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACER1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ACER1 anticorps

Épitope: AA 100-180

Fonction: ASAH3 Antibody

Specificité: ASAH3 Polyclonal Antibody detects endogenous levels of ASAH3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from ASAH3 . at AA range: 100-180

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur ACER1

Antigène: ACER1 (Alkaline Ceramidase 1 (ACER1))

Autre désignation: ASAH3

Sujet:

Synonyms: ACER1, ASAH3, Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3

Background: Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081], Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010],

Gene Name: ACER1

Protein Name: Alkaline ceramidase 1

ID gène: 125981

UniProt: Q8TDN7