CLCF1 anticorps (AA 171-220)

N° du produit ABIN8120206

Cet anticorps anti-CLCF1 Polyclonal Lapin (ABIN8120206) détecte spécifiquement CLCF1 dans IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CLCF1 anticorps (AA 171-220) (ABIN8120206)

Antigène: CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLCF1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-CLCF1 anticorps

Épitope: AA 171-220

Fonction: NNT-1 Antibody

Specificité: The antibody detects endogenous NNT-1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthetic peptide from human protein at AA range: 171-220

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur CLCF1

Antigène: CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))

Autre désignation: NNT-1

Sujet:

Synonyms: Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3, BSF-3, Novel neurotrophin-1, NNT-1)

Background: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encodin

Gene Name: CLCF1 BSF3 CLC NNT1

Protein Name: Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)

ID gène: 23529

UniProt: Q9UBD9

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response