HSD11B1 anticorps (AA 20-50)

N° du produit ABIN8122132

Cet anticorps anti-HSD11B1 Polyclonal Lapin (ABIN8122132) détecte spécifiquement HSD11B1 dans WB, ELISA, IHC et IF. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour HSD11B1 anticorps (AA 20-50) (ABIN8122132)

Antigène: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD11B1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-HSD11B1 anticorps

Épitope: AA 20-50

Fonction: 11β-HSD1 Antibody

Specificité: 11β-HSD1 Polyclonal Antibody detects endogenous levels of 11β-HSD1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from 11beta-HSD1 . at AA range: 20-50

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur HSD11B1

Antigène: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Autre désignation: 11beta-HSD1

Sujet:

Synonyms: HSD11B1, HSD11, HSD11L, Corticosteroid 11-beta-dehydrogenase isozyme 1, 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1

Background: hydroxysteroid 11-beta dehydrogenase 1(HSD11B1) Homo sapiens The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011],

Gene Name: HSD11B1

Protein Name: Corticosteroid 11-beta-dehydrogenase isozyme 1

ID gène: 3290

UniProt: P28845

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process