MASP1 anticorps (Cleaved-Ile449, Light Chain)

N° du produit ABIN8122756

Cet anticorps anti-MASP1 Polyclonal Lapin (ABIN8122756) détecte spécifiquement MASP1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MASP1 anticorps (Cleaved-Ile449, Light Chain) (ABIN8122756)

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MASP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MASP1 anticorps

Épitope: Cleaved-Ile449, Light Chain

Fonction: MASP1 (light chain, Cleaved-Ile449) Antibody

Specificité: This antibody detects endogenous levels of Human MASP1 (light chain, Cleaved-Ile449, protein was cleaved amino acid sequence between 448-449 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human MASP1 (light chain, Cleaved-Ile449)

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur MASP1

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Autre désignation: MASP1

Sujet:

Synonyms: Mannan-binding lectin serine protease 1 (EC 3.4.21.-, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain]

Background: enzyme regulation:Inhibited by SERPING1 and A2M.,function:Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.,PTM:Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. Isoform 1 but not isoform 2 is activated through autoproteolytic processing.,PTM:N-glycosylated. Some N-linked glycan are of the complex-type.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3, triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.,tissue specificity:Protein of the plasma which is primarily expressed by liver.,

Gene Name: MASP1 CRARF CRARF1 PRSS5

Protein Name: MASP1 (light chain, Cleaved-Ile449)

ID gène: 5648

UniProt: P48740

Pathways: Système du Complément