MMP19 anticorps (Cleaved-Tyr98)

N° du produit ABIN8122797

L’anticorps anti-MMP19 Polyclonal Lapin est utilisé pour la détection de MMP19 dans des échantillons de Humain et Souris. Il a été validé pour WB et IHC.

Aperçu rapide pour MMP19 anticorps (Cleaved-Tyr98) (ABIN8122797)

Antigène: MMP19 (Matrix Metallopeptidase 19 (MMP19))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP19 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MMP19 anticorps

Épitope: Cleaved-Tyr98

Fonction: MMP19 (Cleaved-Tyr98) Antibody

Specificité: This antibody detects endogenous levels of Human,Mouse MMP19 (Cleaved-Tyr98, protein was cleaved amino acid sequence between 97-98 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur MMP19

Antigène: MMP19 (Matrix Metallopeptidase 19 (MMP19))

Autre désignation: MMP19

Sujet:

Synonyms: Matrix metalloproteinase-19 (MMP-19, EC 3.4.24.-, Matrix metalloproteinase RASI, Matrix metalloproteinase-18, MMP-18)

Background: alternative products:Additional isoforms seem to exist,catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient.,function:Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.,PTM:Activated by autolytic cleavage after Lys-97.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.,

Gene Name: MMP19 MMP18 RASI

Protein Name: MMP19 (Cleaved-Tyr98)

ID gène: 4327

UniProt: Q99542