Oncostatin M Receptor anticorps (AA 501-550)

N° du produit ABIN8123515

Cet anticorps anti-Oncostatin M Receptor Polyclonal Lapin (ABIN8123515) détecte spécifiquement Oncostatin M Receptor dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Oncostatin M Receptor anticorps (AA 501-550) (ABIN8123515)

Antigène: Oncostatin M Receptor (OSMR)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Oncostatin M Receptor est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Oncostatin M Receptor anticorps

Épitope: AA 501-550

Fonction: IL-31RB Antibody

Specificité: This antibody detects endogenous levels of Human IL-31RB

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human IL-31RB AA range: 501-550

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Oncostatin M Receptor

Antigène: Oncostatin M Receptor (OSMR)

Autre désignation: IL-31RB

Sujet:

Synonyms: Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB)

Background: disease:Defects in OSMR are the cause of amyloidosis type 9 (AMYL9) [MIM:105250], also known as primary cutaneous amyloidosis (PCA), primary localized cutaneous amyloidosis (PLCA), familial lichen amyloidosis or familial cutaneous lichen amyloidosis. AMYL9 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.,induction:Activated by oncostatin-M. Up-regulated by IFNG and lipopolysaccharide.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 4 fibronectin type-III domains.,subunit:Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.,tissue specificity:Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.,

Gene Name: OSMR OSMRB

Protein Name: IL-31RB

ID gène: 9180

UniProt: Q99650

Pathways: Signalistation JAK/STAT, Growth Factor Binding