Progesterone Receptor anticorps (C-Term)

N° du produit ABIN781660

Cet anticorps Souris Monoclonal détecte spécifiquement Progesterone Receptor dans IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Lapin et Poulet.

Aperçu rapide pour Progesterone Receptor anticorps (C-Term) (ABIN781660)

Antigène: Progesterone Receptor (PGR)

Reactivité: Humain, Lapin, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Progesterone Receptor est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: PR-6A

Détail du produit anti-Progesterone Receptor anticorps

Épitope: AA 922-933, C-Term

Specificité: This antibody PR-6A recognizes the Human Progesterone Receptor in the C-terminal ligand-binding domain. Therefore, it recognizes isoforms A and B. Antigen Distribution: Nuclear hormone receptor, widely expressed.

Réactivité croisée (Details): Species reactivity (expected):Chicken and Rabbit.
Species reactivity (tested):Human, Pig.

Purification: Affinity Chromatography

Immunogène: Peptide A922-K933. Epitope: C-terminal region.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore by adding 0.5 mL distilled water

Concentration: 0.2 mg/mL

Buffer: Stock solution contains PBS, pH 7.2 with 5 mg/mL BSA as stabilizer and 0.01 % Kathon as a preservative.

Agent conservateur: Kathon CG

Précaution d'utilisation: This product contains Kathon CG a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Progesterone Receptor

Antigène: Progesterone Receptor (PGR)

Autre désignation: Progesterone Receptor

Sujet: The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. Expressed by a single gene (chromosome 11q22), it has two main forms, A and B, that differ in their molecular weight. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PR determination provides supplementary information to ER, in predicting response to endocrine therapy as well as estimating survival. PR has proved superior to ER as a prognostic indicator in some studies. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.Synonyms: NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3, PGR, PR

ID gène: 5241

NCBI Accession: NP_000917

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration