SMC1A anticorps

N° du produit ABIN781888

Cet anticorps Souris Monoclonal détecte spécifiquement SMC1A dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour SMC1A anticorps (ABIN781888)

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SMC1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 1B9

Détail du produit anti-SMC1A anticorps

Specificité: This antibody reacts to SMC1A / SMC1.

Purification: Protein A chromatography

Immunogène: SMC1A antibody was raised against recombinant protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0,32 mg/mL

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SMC1A

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Autre désignation: SMC1A / SMC1

Sujet: Structural maintenance of chromosome proteins (SMC) are involved in chromosome cohesion during cell cycle and in DNA repair as part of the of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint The form of SMC1A phosphorylated at Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function.Synonyms: DXS423E, SB1.8, SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1L1, Structural maintenance of chromosomes protein 1A

ID gène: 8243

NCBI Accession: NP_006297

UniProt: Q14683

Pathways: Stem Cell Maintenance