CDK5 anticorps

N° du produit ABIN782438

Il existe 1 publication pour ce produit. L’anticorps anti-CDK5 Monoclonal Souris est utilisé pour la détection de CDK5 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et IHC (fro).

Aperçu rapide pour CDK5 anticorps (ABIN782438)

Antigène: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 1H3

Détail du produit anti-CDK5 anticorps

Specificité: Specific for the ~ 28 kDa Cdk5 protein in Western blots of Rat striatal lysate. The antibody shows no cross reactivity with the CDK5 cofactor p35 or its degradation product p25.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Protein G Chromatography.

Immunogène: Purified Rat Cdk5.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C.

Références pour anticorps anti-CDK5 (ABIN782438)

Amin, Zheng, Bk, Shukla, Skuntz, Grant, Steiner, Bhaskar, Pant: "The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35." dans: Molecular biology of the cell, Vol. 27, Issue 21, pp. 3221-3232, (2017) (PubMed).

Détails sur CDK5

Antigène: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Autre désignation: CDK5

Sujet: The neuronal protein kinase, Cdk5 has been implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis (Kansy J et al., 2004), the presynaptic vesicle cycle (Nguyen, C. & Bibb, JA 2003), neurotransmitter receptor trafficking and dopamine neurotransmission (Bibb, JA et al. 1999). At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer's, Parkinson's, Huntington's, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology.Synonyms: Cell division protein kinase 5, Cyclin-dependent kinase 5, PSSALRE, Serine/threonine-protein kinase PSSALRE, TPKII catalytic subunit, Tau protein kinase II catalytic subunit

ID gène: 140908

NCBI Accession: NP_543161

UniProt: Q03114

Pathways: Cycle Cellulaire, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis