Synaptojanin 1 anticorps (C-Term)

N° du produit ABIN782444

Détail du produit anti-Synaptojanin 1 anticorps

Antigène: Synaptojanin 1 (SYNJ1)

Épitope: C-Term

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Synaptojanin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: Specific for the ~145k Synaptojanin I protein in Western blots of Rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody. Does not cross react with Mouse.

Réactivité croisée (Details): Species reactivity (tested):Rat.

Purification: Protein G Chromatography of Culture Supernatant.

Immunogène: Recombinant protein corresponding to amino acid residues from the C-terminal region of Rat Synaptojanin 1.

Clone: 5H1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C.

Détails sur Synaptojanin 1

Antigène: Synaptojanin 1 (SYNJ1)

Autre désignation: Synaptojanin-1 / SYNJ1 (SYNJ1 Produits)

Synonymes: anticorps CG6562, anticorps Dmel\\CG6562, anticorps IPP, anticorps Synj, anticorps fb02f11, anticorps fi15a11, anticorps nrc, anticorps wu:fb02f11, anticorps wu:fi15a11, anticorps SYNJ1, anticorps INPP5G, anticorps A930006D20Rik, anticorps AA675315, anticorps mKIAA0910, anticorps Synaptojanin, anticorps synaptojanin 1, anticorps Synj, anticorps synj1, anticorps SYNJ1, anticorps Synj1

Sujet: Synaptojanin is a phosphatidylinositol phosphatase involved in clathrinmediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms, one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidyl-inositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).Synonyms: 4, 5-trisphosphate 5-phosphatase 1, INPP5G, KIAA0910, Synaptic Marker, Synaptic inositol-1

ID gène: 85238

NCBI Accession: NP_445928

UniProt: Q62910

Pathways: Inositol Metabolic Process, Synaptic Vesicle Exocytosis