Aggrecan anticorps (N-Term)

N° du produit ABIN782461

Cet anticorps Lapin Polyclonal détecte spécifiquement Aggrecan dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Aggrecan anticorps (N-Term) (ABIN782461)

Antigène: Aggrecan (ACAN)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aggrecan est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Aggrecan anticorps

Épitope: N-Term

Réactivité croisée (Details): Species reactivity (tested):Human.

Immunogène: Synthetic peptide (- KLH conjugated) corresponding to N-terminal domain of Human Aggrecan.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Détails sur Aggrecan

Antigène: Aggrecan (ACAN)

Autre désignation: Aggrecan

Sujet: Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.Synonyms: ACAN, AGC1, CSPG1, Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1, MSK16

ID gène: 9606

UniProt: P16112

Pathways: Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport