AXIN2 anticorps (C-Term)

N° du produit ABIN783373

Cet anticorps Lapin Polyclonal détecte spécifiquement AXIN2 dans WB et EIA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour AXIN2 anticorps (C-Term) (ABIN783373)

Antigène: AXIN2 (Axin 2 (AXIN2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AXIN2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-AXIN2 anticorps

Épitope: C-Term

Specificité: Thias antibody detects Axin-2 at C-term. It is predicted to not cross-react with AXIN2. At least four isoforms of AXIN2 are known to exist, this antibody will recognize all four.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 20 amino acid peptide near the carboxy terminus of human AXIN2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur AXIN2

Antigène: AXIN2 (Axin 2 (AXIN2))

Autre désignation: Axin-2

Sujet: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.Synonyms: AXIN2, Axin-like protein, Axis inhibition protein 2, Conductin

ID gène: 8313

NCBI Accession: NP_004646

UniProt: Q9Y2T1

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling