LRRTM3 anticorps (C-Term)

N° du produit ABIN783383

Détail du produit anti-LRRTM3 anticorps

Antigène: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Épitope: C-Term

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRRTM3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibnody detects LRRTM3 at C-term. At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the carboxy terminus of human LRRTM3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur LRRTM3

Antigène: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Autre désignation: LRRTM3 (LRRTM3 Produits)

Sujet: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the β-secretase BACE, leading to the proteolytic production of the Aβ42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Aβ42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.Synonyms: Leucine-rich repeat transmembrane neuronal protein 3

ID gène: 26045

NCBI Accession: NP_056379

UniProt: Q86VH5

Pathways: Synaptic Membrane