GLS2 anticorps (Center)

N° du produit ABIN783413

L’anticorps Lapin Polyclonal anti-GLS2 a été validé pour WB et EIA. Il convient pour détecter GLS2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GLS2 anticorps (Center) (ABIN783413)

Antigène: GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLS2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-GLS2 anticorps

Épitope: Center

Specificité: This antibody detects Glutaminase liver isoform at Center. GLS2 antibody is predicted to not cross-react with other catenin family members. Multiple isoforms of GLS2 are known to exist.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the center terminus of human GLS2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur GLS2

Antigène: GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))

Sujet: Phosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and ?-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53's role in antioxidant defense in addition to its role in energy metabolism.Synonyms: GA, GLS2, L-glutaminase, L-glutamine amidohydrolase

ID gène: 27165

NCBI Accession: NP_037399

UniProt: Q9UI32

Pathways: Dicarboxylic Acid Transport, L'effet Warburg