DYRK2 anticorps (C-Term)

N° du produit ABIN783436

Cet anticorps Lapin Polyclonal détecte spécifiquement DYRK2 dans WB et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour DYRK2 anticorps (C-Term) (ABIN783436)

Antigène: DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DYRK2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-DYRK2 anticorps

Épitope: C-Term

Specificité: This antibody detects DYRK2 at C-term. Two isoforms of DYRK2 are known to exist, this antibody will recognize both isoforms. DYRK2 antibody will not cross-react with other DYRK family members.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the carboxy terminus of human DYRK2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur DYRK2

Antigène: DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))

Autre désignation: DYRK2

Sujet: DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2

ID gène: 8445

NCBI Accession: NP_003574

UniProt: Q92630

Pathways: Regulation of Carbohydrate Metabolic Process