IDH2 anticorps (C-Term)

N° du produit ABIN783626

Détail du produit anti-IDH2 anticorps

Antigène: IDH2 (Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IDH2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide near the carboxy terminus of human IDH1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur IDH2

Antigène: IDH2 (Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))

Autre désignation: Isocitrate Dehydrogenase / IDH2 (IDH2 Produits)

Synonymes: anticorps F6P23.14, anticorps F6P23_14, anticorps IDH-II, anticorps NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2, anticorps isocitrate dehydrogenase II, anticorps isocitrate dehydrogenase subunit 2, anticorps D2HGA2, anticorps ICD-M, anticorps IDH, anticorps IDHM, anticorps IDP, anticorps IDPM, anticorps mNADP-IDH, anticorps E430004F23, anticorps IDPm, anticorps Idh-2, anticorps wu:fb33c06, anticorps wu:fk31e05, anticorps wu:fq43b01, anticorps zgc:55485, anticorps idh2, anticorps IDH2, anticorps isocitrate dehydrogenase subunit 2, anticorps isocitrate dehydrogenase (NADP(+)) 2, mitochondrial, anticorps isocitrate dehydrogenase 2 (NADP+), mitochondrial, anticorps isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog, anticorps isocitrate dehydrogenase [NADP], mitochondrial, anticorps IDH2, anticorps Idh2, anticorps idh2.S, anticorps idh2, anticorps LOC100441867

Sujet: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. The presence of IDH1 in peroxisomes suggests it may play a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic IDH1 serves a significant role in cytoplasmic NADPH production. Defects in IDH1 are involved in the development of glioma.Synonyms: ICD-M, ICDH, IDP, NADP(+)-specific ICDH, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Oxalosuccinate decarboxylase

ID gène: 3418

NCBI Accession: NP_002159

UniProt: P48735

Pathways: L'effet Warburg