SIP1 anticorps (C-Term)

N° du produit ABIN783630

Détail du produit anti-SIP1 anticorps

Antigène: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide near the carboxy terminus of human SIP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur SIP1

Antigène: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Autre désignation: SIP1 / GEMIN2 (GEMIN2 Produits)

Synonymes: anticorps SIP1, anticorps SIP1-delta, anticorps 1700012N19Rik, anticorps Sip1, anticorps sip1, anticorps sip1-delta, anticorps wu:fc52a05, anticorps zgc:110274, anticorps gem nuclear organelle associated protein 2, anticorps gem (nuclear organelle) associated protein 2, anticorps gem nuclear organelle associated protein 2 S homeolog, anticorps GEMIN2, anticorps Gemin2, anticorps gemin2.S, anticorps gemin2

Sujet: SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.Synonyms: Component of gems 2, GEMIN-2, SMN-interacting protein 1, Survival of motor neuron protein-interacting protein 1

ID gène: 8487

NCBI Accession: NP_001009182

UniProt: O14893

Pathways: Ribonucleoprotein Complex Subunit Organization, Tube Formation