ATG13 anticorps (C-Term)

N° du produit ABIN783663

Détail du produit anti-ATG13 anticorps

Antigène: ATG13 (Autophagy Related 13 (ATG13))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG13 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide near the carboxy terminus of human ATG13

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur ATG13

Antigène: ATG13 (Autophagy Related 13 (ATG13))

Autre désignation: KIAA0652 (ATG13 Produits)

Synonymes: anticorps zgc:63526, anticorps KIAA0652, anticorps PARATARG8, anticorps 1110053A20Rik, anticorps D2Ertd391e, anticorps Harbi1, anticorps Harbi1l, anticorps RGD1310685, anticorps autophagy related 13, anticorps ATG13 autophagy related 13 homolog (S. cerevisiae), anticorps ATG13, anticorps atg13, anticorps Atg13

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions, inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.Synonyms: UPF0630 protein KIAA0652

ID gène: 9776

NCBI Accession: NP_001136145

UniProt: O75143

Pathways: Signalisation PI3K-Akt, Autophagy