NLRP7 anticorps (N-Term)

N° du produit ABIN783711

Détail du produit anti-NLRP7 anticorps

Antigène: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP7 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects NLRP7 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the amino terminus of human NALP7

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur NLRP7

Antigène: NLRP7 (NLR Family, Pyrin Domain Containing 7 (NLRP7))

Autre désignation: NLRP7 (NLRP7 Produits)

Synonymes: anticorps CLR19.4, anticorps HYDM, anticorps NALP7, anticorps NOD12, anticorps PAN7, anticorps PYPAF3, anticorps NLR family pyrin domain containing 7, anticorps NLRP7

Sujet: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.Synonyms: LRR and PYD domains-containing protein 7, NALP7, NOD12, Nucleotide-binding oligomerization domain protein 12, PYPAF3, PYRIN-containing APAF1-like protein 3

ID gène: 199713

NCBI Accession: NP_001120727

UniProt: Q8WX94

Pathways: Inflammasome