BANP anticorps (Center)

N° du produit ABIN783725

Détail du produit anti-BANP anticorps

Antigène: BANP (Protein BANP (BANP))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BANP est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects BANP / SMAR1 at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 14 amino acid peptide near the center of human BANP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Antibody is supplied in PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur BANP

Antigène: BANP (Protein BANP (BANP))

Autre désignation: BANP / SMAR1 (BANP Produits)

Synonymes: anticorps smar1, anticorps smarbp1, anticorps MGC76079, anticorps MGC89601, anticorps BEND1, anticorps SMAR1, anticorps SMARBP1, anticorps AA408158, anticorps zgc:111954, anticorps BTG3 associated nuclear protein, anticorps Btg3 associated nuclear protein, anticorps BTG3 associated nuclear protein L homeolog, anticorps banp, anticorps BANP, anticorps Banp, anticorps banp.L

Sujet: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-b signaling. Furthermore, BANP can modulate NF-kB transactivation and can inhibit tumorigenesis by regulating NF-kB target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.Synonyms: BEN domain-containing protein 1, BEND1, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein

ID gène: 54971

NCBI Accession: NP_001167010

UniProt: Q8N9N5