KPNA6 anticorps (N-Term)

N° du produit ABIN783737

Détail du produit anti-KPNA6 anticorps

Antigène: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA6 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects KPNA6 / Importin alpha-7 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide near the amino terminus of human KPNA6

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur KPNA6

Antigène: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Autre désignation: KPNA6 / Importin alpha-7 (KPNA6 Produits)

Synonymes: anticorps IPOA7, anticorps Kpna5, anticorps NPI-2, anticorps KPNA7, anticorps karyopherin subunit alpha 6, anticorps karyopherin (importin) alpha 6, anticorps karyopherin alpha 6 (importin alpha 7), anticorps karyopherin alpha 6 (importin alpha 7) S homeolog, anticorps KPNA6, anticorps Kpna6, anticorps kpna6.S

Sujet: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.Synonyms: IPOA7, KPNA6, Karyopherin subunit alpha-6

ID gène: 23633

NCBI Accession: NP_036448

UniProt: O60684

Pathways: Protein targeting to Nucleus