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CXXC4 anticorps (N-Term)

CXXC4 Reactivité: Humain, Souris, Rat WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN783773
  • Antigène Voir toutes CXXC4 Anticorps
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Épitope
    • 10
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    N-Term
    Reactivité
    • 22
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 21
    • 1
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CXXC4 est non-conjugé
    Application
    • 21
    • 16
    • 16
    • 14
    • 4
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects CXXC4 at N-term.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    18 amino acid peptide near the amino terminus of human CXXC4
    Top Product
    Discover our top product CXXC4 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Antigène
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Autre désignation
    CXXC4 (CXXC4 Produits)
    Synonymes
    anticorps 9330210J02Rik, anticorps C030003J12Rik, anticorps Idax, anticorps IDAX, anticorps Xldax, anticorps xIdax, anticorps CXXC finger 4, anticorps CXXC finger protein 4, anticorps CXXC finger protein 4 S homeolog, anticorps Cxxc4, anticorps CXXC4, anticorps cxxc4.S
    Sujet
    CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.Synonyms: CXXC-type zinc finger protein 4, IDAX, Inhibition of the Dvl and axin complex protein
    ID gène
    80319
    NCBI Accession
    NP_079488
    UniProt
    Q9H2H0
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