PKDCC anticorps (Center)

N° du produit ABIN783833

L’anticorps Lapin Polyclonal anti-PKDCC a été validé pour WB et EIA. Il convient pour détecter PKDCC dans des échantillons de Humain, Souris et Rat. Il y a 2+ publications disponibles.

Aperçu rapide pour PKDCC anticorps (Center) (ABIN783833)

Antigène: PKDCC (Protein Kinase Domain Containing, Cytoplasmic Homolog (Mouse) (PKDCC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKDCC est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-PKDCC anticorps

Épitope: Center

Purification: Affinity chromatography

Immunogène: 15 amino acid peptide from near the center of human VLK.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Références pour anticorps anti-PKDCC (ABIN783833)

Maddala, Skiba, Rao: "Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells." dans: Journal of cellular physiology, Vol. 232, Issue 9, pp. 2447-2460, (2017) (PubMed).

Bordoli, Yum, Breitkopf, Thon, Italiano, Xiao, Worby, Wong, Lin, Edenius, Keller, Asara, Dixon, Yeo, Whitman: "A secreted tyrosine kinase acts in the extracellular environment." dans: Cell, Vol. 158, Issue 5, pp. 1033-44, (2014) (PubMed).

Détails sur PKDCC

Antigène: PKDCC (Protein Kinase Domain Containing, Cytoplasmic Homolog (Mouse) (PKDCC))

Autre désignation: PKDCC

Sujet: VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.Synonyms: LOC91461, Protein kinase domain-containing protein, Protein kinase-like protein SgK493, Sugen kinase 493, VLK, Vertebrate lonesome kinase

ID gène: 91461

NCBI Accession: NP_612379

UniProt: Q504Y2